Anti-Adalimumab monoclonal antibody, clone 3C2
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More Files
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Enzyme-linked Immunoabsorbent Assay
Anti-Adalimumab monoclonal antibody, clone 3C2 (Cat # MAB23126) binds with Adalimumab. Coating antigen: Adalimumab, 1 ug/mL. Anti-Adalimumab monoclonal antibody, clone 3C2 (Cat # MAB23126) dilution start from 1000 ng/mL. EC50 = 6.571 ng/mL. While the antibody does not recognize the human IgG Fc fragment (data not shown).
Sandwich ELISA
Standard curve of Adalimumab Sandwich ELISA. The Adalimumab Sandwich ELISA assay is developed by using Anti-Adalimumab monoclonal antibody, clone 15C7 (Cat # MAB23125) and Anti-Adalimumab monoclonal antibody, clone 3C2 (Cat # MAB23126) as the capture and detection antibodies, respectively. In this ELISA assay, Anti-Adalimumab monoclonal antibody, clone 3C2 (Cat # MAB23126) was labeled with Biotin. The sensitivity of detecting Rituximab is about 300 pg/mL.
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Specification
Product Description
Mouse monoclonal antibody raised against Adalimumab.
Target gene is TNF alpha.Immunogen
Adalimumab.
Host
Mouse
Specificity
The product is specific for Adalimumab. The antibody is recommended as a detection antibody in a pharmacokinetic (PK) bridging assay with capture antibody Anti-Adalimumab monoclonal antibody, clone 15C7 (Cat # MAB23125).
Form
Lyophilized
Purification
Protein A purification
Isotype
IgG1, kappa
Recommend Usage
ELISA (ELISA detection: 0.005-0.1 ug/mL) (Direct/Indirect ELISA)
Sandwich ELISA
The optimal working dilution should be determined by the end user.Inhibitory IC50
Non-inhibitory
Storage Buffer
Lyophilized from PBS, pH 7.4 (0.02% sodium azide).
Storage Instruction
Store at -20°C on dry atmosphere, lyophilized antibodies are stable at 1 years.
After reconstitution with deionized water (or equivalent) to a final concentration of 0.5 mg/mL, it can be stored for 2-3 weeks at 2-8°C or for up to 12 months at -20°C or below.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
Anti-Adalimumab monoclonal antibody, clone 3C2 (Cat # MAB23126) binds with Adalimumab. Coating antigen: Adalimumab, 1 ug/mL. Anti-Adalimumab monoclonal antibody, clone 3C2 (Cat # MAB23126) dilution start from 1000 ng/mL. EC50 = 6.571 ng/mL. While the antibody does not recognize the human IgG Fc fragment (data not shown).Sandwich ELISA
Standard curve of Adalimumab Sandwich ELISA. The Adalimumab Sandwich ELISA assay is developed by using Anti-Adalimumab monoclonal antibody, clone 15C7 (Cat # MAB23125) and Anti-Adalimumab monoclonal antibody, clone 3C2 (Cat # MAB23126) as the capture and detection antibodies, respectively. In this ELISA assay, Anti-Adalimumab monoclonal antibody, clone 3C2 (Cat # MAB23126) was labeled with Biotin. The sensitivity of detecting Rituximab is about 300 pg/mL. -
Gene Info — TNF
Entrez GeneID
7124Gene Name
TNF
Gene Alias
DIF, TNF-alpha, TNFA, TNFSF2
Gene Description
tumor necrosis factor (TNF superfamily, member 2)
Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq
Other Designations
APC1 protein|OTTHUMP00000029281|OTTHUMP00000037669|TNF superfamily, member 2|TNF, macrophage-derived|TNF, monocyte-derived|cachectin|tumor necrosis factor alpha
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Interactome
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Pathway
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Disease
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