TNF recombinant monoclonal antibody, clone CDP 571 (Humicade)
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Specification
Product Description
Human recombinant monoclonal antibody raised against human TNF-alpha.
Antibody Species
Human
Immunogen
Original antibody is raised against recombinant protein corresponding to human TNF-alpha.
Reactivity
Human
Form
Liquid
Isotype
IgG4 kappa
Recommend Usage
ELISA
NTRL
Immunohistochemistry
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% Proclin 300)
Storage Instruction
Store at 4°C for 3 months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Western blot analysis of rat liver, rat spinal cord, mouse testis, rat colon, human thyroid tumour tissue lysate using anti-TNF alpha recombinant monoclonal antibody, clone CDP 571 (Humicade) (Cat # RAB03909).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Formalin-fixed paraffin-embedded sections) of rat liver with anti-TNF alpha recombinant monoclonal antibody, clone CDP 571 (Humicade) (Cat # RAB03909).Enzyme-linked Immunoabsorbent Assay
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Gene Info — TNF
Entrez GeneID
7124Protein Accession#
P01375Gene Name
TNF
Gene Alias
DIF, TNF-alpha, TNFA, TNFSF2
Gene Description
tumor necrosis factor (TNF superfamily, member 2)
Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq
Other Designations
APC1 protein|OTTHUMP00000029281|OTTHUMP00000037669|TNF superfamily, member 2|TNF, macrophage-derived|TNF, monocyte-derived|cachectin|tumor necrosis factor alpha
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