TNF recombinant monoclonal antibody, clone cA2 (Infliximab)
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More Files
- More Functions
Western Blot
Western Blot analysis were resolved on a 10% SDS PAGE gel and blots probed at 1.5 ug/mL before being detected by a secondary antibody. The expected band size (26.9 kDa) is seen in the human-derived samples, as well as a band corresponding to dimers.
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Specification
Product Description
Mouse recombinant monoclonal antibody raised against human TNF alpha.
Antibody Species
Mouse
Immunogen
Original antibody is raised against purified recombinant human TNF (rTNF).
Reactivity
Human
Specificity
Binds to soluble and transmembrane forms of TNF-alpha and neutralizes its biological activity. Does not bind to TNF-beta.
Form
Liquid
Purification
Protein A affinity purification
Isotype
IgG2a, Kappa
Recommend Usage
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS with 0.02% Proclin 300
Storage Instruction
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
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Applications
Western Blot
Western Blot analysis were resolved on a 10% SDS PAGE gel and blots probed at 1.5 ug/mL before being detected by a secondary antibody. The expected band size (26.9 kDa) is seen in the human-derived samples, as well as a band corresponding to dimers. -
Gene Info — TNF
Entrez GeneID
7124Protein Accession#
P01375Gene Name
TNF
Gene Alias
DIF, TNF-alpha, TNFA, TNFSF2
Gene Description
tumor necrosis factor (TNF superfamily, member 2)
Gene Ontology
HyperlinkGene Summary
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, and cancer. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq
Other Designations
APC1 protein|OTTHUMP00000029281|OTTHUMP00000037669|TNF superfamily, member 2|TNF, macrophage-derived|TNF, monocyte-derived|cachectin|tumor necrosis factor alpha
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Interactome
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Pathway
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Disease
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