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Immunofluorescence

Immunofluorescent staining of Jurkat cells with CD8A recombinant monoclonal antibody, clone RIV11 (Cat # RAB03355).
Immunofluorescence analysis of paraformaldehyde Jurkat cells fixed on Shi-fix™ coverslips stained with the chimeric r version of RAB03355 at 10 ug/mL for 1h followed by Alexa Fluor® 488 secondary antibody (2 ug/mL), showing membrane staining. The nuclear stain is DAPI (blue). The isotype control was stained with an unknown specificity antibody followed by staining with Alexa Fluor® 488 secondary antibody.
(A) RAB03355
(B) DAPI
(C) Merged channels
(D) Isotype control

Flow Cytometry

Entrez GeneID

925

Gene Name

CD8A

Gene Alias

CD8, Leu2, MAL, p32

Gene Description

CD8a molecule

Omim ID

186910 608957

Gene Ontology

Hyperlink

Gene Summary

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a corepressor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains, or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain isoforms. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

CD8 antigen alpha polypeptide|CD8 antigen, alpha polypeptide (p32)|Leu2 T-lymphocyte antigen|OKT8 T-cell antigen|T cell co-receptor|T-cell antigen Leu2|T-cell surface glycoprotein CD8 alpha chain|T-lymphocyte differentiation antigen T8/Leu-2|T8 T-cell ant