Formalin-fixed and paraffin-embedded human placenta (A, 4 µm) and squamous cell skin carcinoma (B, 4 µm) stained with EGFR monoclonal antibody, clone A20-E (Cat # MAB9774) shows strong positive membrane immunostaining of syncytiotrophoblasts (A) and strong membrane staining of tumor cells (B). Kindly performed and provided by Katarina Poliakova, MD and L'ubomir Straka, MD, Ph. D. from Clinical Pathology Presov, Ltd., Presov, Slovak republic.
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. [provided by RefSeq
avian erythroblastic leukemia viral (v-erb-b) oncogene homolog,cell growth inhibiting protein 40,cell proliferation-inducing protein 61,epidermal growth factor receptor