MMP1 monoclonal antibody, clone SB12e
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Specification
Product Description
Mouse monoclonal antibody raised against recombinant MMP1.
Immunogen
Recombinant protein corresponding to human MMP1.
Host
Mouse
Reactivity
Human
Specificity
human MMP-1, Does not cross react to human MMP-2, MMP-3 or MMP-9.
Form
Liquid
Isotype
IgG2b
Recommend Usage
ELISA (1:3000-1:8000)
Immunohistochemistry (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 100 mM BBS, pH 8.2
Storage Instruction
Store at 4°C.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Enzyme-linked Immunoabsorbent Assay
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Gene Info — MMP1
Entrez GeneID
4312Gene Name
MMP1
Gene Alias
CLG, CLGN
Gene Description
matrix metallopeptidase 1 (interstitial collagenase)
Gene Ontology
HyperlinkGene Summary
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq
Other Designations
fibroblast collagenase|interstitial collagenase|matrix metalloprotease 1|matrix metalloproteinase 1|matrix metalloproteinase 1 (interstitial collagenase)
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Interactome
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Pathway
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Disease
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Publication Reference
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Degradation of interleukin 1beta by matrix metalloproteinases.
Ito A, Mukaiyama A, Itoh Y, Nagase H, Thogersen IB, Enghild JJ, Sasaguri Y, Mori Y.
The Journal of Biological Chemistry 1996 Jun; 271(25):14657.
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Metalloproteinase-mediated regulation of L-selectin levels on leucocytes.
Preece G, Murphy G, Ager A.
The Journal of Biological Chemistry 1996 May; 271(20):11634.
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Matrix metalloproteinases degrade myelin basic protein.
Chandler S, Coates R, Gearing A, Lury J, Wells G, Bone E.
Neuroscience Letters 1995 Dec; 201(3):223.
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Degradation of interleukin 1beta by matrix metalloproteinases.
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