CBL monoclonal antibody (M01A), clone 6D12
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More Files
- More Functions
Western Blot (Cell lysate)
CBL monoclonal antibody (M01A), clone 6D12 Western Blot analysis of CBL expression in K-562 ( Cat # L009V1 ).
Western Blot (Transfected lysate)
Western Blot analysis of CBL expression in transfected 293T cell line by CBL monoclonal antibody (M01A), clone 6D12.
Lane 1: CBL transfected lysate (Predicted MW: 99.6 KDa).
Lane 2: Non-transfected lysate.
Western Blot detection against Immunogen (36.74 KDa) .
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Specifications
Product Description
Mouse monoclonal antibody raised against a partial recombinant CBL.
Immunogen
CBL (NP_005179, 736 a.a. ~ 835 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Sequence
NIQSQAPSITESSTFGEGNLAAAHANTGPEESENEDDGYDVPKPPVPAVLARRTLSDISNASSSFGWLSLDGDPTTNVTEGSQVPERPPKPFPRRINSER
Host
Mouse
Reactivity
Human
Isotype
IgG1 Kappa
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Western Blot detection against Immunogen (36.74 KDa) .
Storage Buffer
In ascites fluid
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
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Applications
Western Blot (Cell lysate)
CBL monoclonal antibody (M01A), clone 6D12 Western Blot analysis of CBL expression in K-562 ( Cat # L009V1 ).Western Blot (Transfected lysate)
Western Blot analysis of CBL expression in transfected 293T cell line by CBL monoclonal antibody (M01A), clone 6D12.
Lane 1: CBL transfected lysate (Predicted MW: 99.6 KDa).
Lane 2: Non-transfected lysate.
Western Blot (Recombinant protein)
ELISA
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Gene Info — CBL
Entrez GeneID
867GeneBank Accession#
NM_005188Protein Accession#
NP_005179Gene Name
CBL
Gene Alias
C-CBL, CBL2, RNF55
Gene Description
Cas-Br-M (murine) ecotropic retroviral transforming sequence
Omim ID
165360Gene Ontology
HyperlinkGene Summary
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq
Other Designations
oncogene CBL2
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Interactomes
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Pathways
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Diseases
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