CBL recombinant monoclonal antibody, clone CblY774-R3B8
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of 3T3 cells secondary antibody only negative control (blue) or untreated (gray) or treated with IFNa + IL-4 + pervanadate (orange) using 0.1 ug/mL isotype control or untreated (red) or treated (green) using Phospho-c-Cbl (Tyr774) antibody CblY774-R3B8 at 0.01 ug/mL.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CBL.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr774 of human phospho c-Cbl
Reactivity
Human
Form
Liquid
Purification
Protein A+G
Isotype
Rabbit IgG1k
Recommend Usage
Flow Cytometry
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.02% Sodium azide, 50% Glycerol, 0.1% BSA
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of 3T3 cells secondary antibody only negative control (blue) or untreated (gray) or treated with IFNa + IL-4 + pervanadate (orange) using 0.1 ug/mL isotype control or untreated (red) or treated (green) using Phospho-c-Cbl (Tyr774) antibody CblY774-R3B8 at 0.01 ug/mL. -
Gene Info — CBL
Entrez GeneID
867Protein Accession#
P22681Gene Name
CBL
Gene Alias
C-CBL, CBL2, RNF55
Gene Description
Cas-Br-M (murine) ecotropic retroviral transforming sequence
Omim ID
165360Gene Ontology
HyperlinkGene Summary
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq
Other Designations
oncogene CBL2
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Interactome
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Pathway
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Disease
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