CBL recombinant monoclonal antibody, clone CblY774-R3B8 (APC)
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More Files
- More Functions
Flow Cytometry
Flow cytometric analysis of Daudi cells cell only (blue) or untreated (red) or treated with IFNα + IL-4 + pervanadate (green) using Phospho-c-Cbl (Tyr774) APC-conjugated antibody CblY774-R3B8.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human CBL.
Antibody Species
Rabbit
Immunogen
A synthetic phospho-peptide corresponding to residues surrounding Tyr774 of human phospho c-Cbl
Reactivity
Human
Form
Liquid
Conjugation
APC
Purification
Protein A purification, Protein G purification
Isotype
IgG
Recommend Usage
Flow Cytometry
The optimal working dilution should be determined by the end user.Storage Buffer
1X PBS, 0.09% Sodium azide, 0.2% BSA
Storage Instruction
Store at 4°C. Do not freeze.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Flow Cytometry
Flow cytometric analysis of Daudi cells cell only (blue) or untreated (red) or treated with IFNα + IL-4 + pervanadate (green) using Phospho-c-Cbl (Tyr774) APC-conjugated antibody CblY774-R3B8. -
Gene Info — CBL
Entrez GeneID
867Protein Accession#
P22681Gene Name
CBL
Gene Alias
C-CBL, CBL2, RNF55
Gene Description
Cas-Br-M (murine) ecotropic retroviral transforming sequence
Omim ID
165360Gene Ontology
HyperlinkGene Summary
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq
Other Designations
oncogene CBL2
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Interactome
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Pathway
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Disease
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