IGH/SOX5 DY Translocation FISH Probe

Catalog # FT0010

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Size:200 uL
Price: USD $ 2,122.00
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Size:100 uL
Price: USD $ 1,288.00
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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
Images
Fluorescent <i>In Situ</i> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Application

Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)

Human prostate (FFPE) stained with IGH/SOX5,DY FISH Probe. Human prostate showed no IGH/SOX5 translocation.

QC Test

Hybridization position of the probes on the chromosome.
Note

Hybridization position of the probes on the chromosome.

Hybridization position of the probes on the chromosome.

  • Specification

    Product Description

    Labeled FISH probes for identification of gene translocation using Fluorescent In Situ Hybridization Technique. (Technology)

    Probe 1

    Name: IGH
    Size: Approximately 1550kb
    Fluorophore: FITC
    Location: 14q32

    Probe 2

    Name: SOX5
    Size: Approximately 1200kb
    Fluorophore: Texas Red
    Location: 12p12.2

    Origin

    Human

    Source

    Genomic DNA

    Reactivity

    Human

    Form

    Liquid

    Notice

    We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.

    Regulation Status

    For research use only (RUO)

    Quality Control Testing

    Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    Supplied Product

    DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe

    Storage Instruction

    Store at 4°C in the dark.

    Note

    Hybridization position of the probes on the chromosome.

  • Applications

    Fluorescent In Situ Hybridization (Cell)

    Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)

    Human prostate (FFPE) stained with IGH/SOX5,DY FISH Probe. Human prostate showed no IGH/SOX5 translocation.
  • Gene Info — IGH

    Entrez GeneID

    3492

    Gene Name

    IGH

    Gene Alias

    IGH, IGH.1@, IGHDY1, MGC72071, MGC88774

    Gene Description

    immunoglobulin heavy locus

    Gene Ontology

    Hyperlink

    Gene Summary

    Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V, D, J, and C segments are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq

    Other Designations

    -

  • Gene Info — SOX5

    Entrez GeneID

    6660

    Gene Name

    SOX5

    Gene Alias

    L-SOX5, MGC35153

    Gene Description

    SRY (sex determining region Y)-box 5

    Omim ID

    604975

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq

    Other Designations

    -

  • Interactome
  • Disease
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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