IGH/MALT1 Translocation FISH Probe

Catalog # FT0031

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Size:200 uL
Price: USD $ 2,122.00
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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
Images
QC Test

Hybridization position of the probes on the chromosome.
Note

Hybridization position of the probes on the chromosome.

Hybridization position of the probes on the chromosome.

  • Specifications

    Product Description

    Labeled FISH probes for identification of gene translocation using Fluorescent In Situ Hybridization Technique. (Technology).

    Probe 1

    Name: IGH
    Size: Approximately 1550kb
    Fluorophore: FITC
    Location: 14q32

    Probe 2

    Name: MALT1
    Size: Approximately 970kb
    Fluorophore: Texas Red
    Location: 18q21

    Origin

    Human

    Source

    Genomic DNA

    Reactivity

    Human

    Notice

    We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.

    Regulatory Status

    For research use only (RUO)

    Quality Control Testing

    Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    Storage Instruction

    Store at 4°C in the dark.

    Note

    Hybridization position of the probes on the chromosome.

  • Applications

    Fluorescent In Situ Hybridization (Cell)

  • Gene Info — IGH

    Entrez GeneID

    3492

    Gene Name

    IGH

    Gene Alias

    IGH, IGH.1@, IGHDY1, MGC72071, MGC88774

    Gene Description

    immunoglobulin heavy locus

    Gene Ontology

    Hyperlink

    Gene Summary

    Immunoglobulins recognize foreign antigens and initiate immune responses such as phagocytosis and the complement system. Each immunoglobulin molecule consists of two identical heavy chains and two identical light chains. This region represents the germline organization of the heavy chain locus. The locus includes V (variable), D (diversity), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single D segment with a J segment; this partially rearranged D-J gene is then joined to a V segment. The rearranged V-D-J is then transcribed with the IGHM constant region; this transcript encodes a mu heavy chain. Later in development B cells generate V-D-J-Cmu-Cdelta pre-messenger RNA, which is alternatively spliced to encode either a mu or a delta heavy chain. Mature B cells in the lymph nodes undergo switch recombination, so that the V-D-J gene is brought in proximity to one of the IGHG, IGHA, or IGHE genes and each cell expresses either the gamma, alpha, or epsilon heavy chain. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. Several V, D, J, and C segments are known to be incapable of encoding a protein and are considered pseudogenes. [provided by RefSeq

    Other Designations

    -

  • Gene Info — MALT1

    Entrez GeneID

    10892

    Gene Name

    MALT1

    Gene Alias

    DKFZp434L132, MLT, MLT1

    Gene Description

    mucosa associated lymphoid tissue lymphoma translocation gene 1

    Omim ID

    604860

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene has been found to be recurrently rearranged in chromosomal translocation with two other genes - baculoviral IAP repeat-containing protein 3 (also known as apoptosis inhibitor 2) and immunoglobulin heavy chain locus - in mucosa-associated lymphoid tissue lymphomas. The protein encoded by this gene may play a role in NF-kappaB activation. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq

    Other Designations

    MALT associated translocation|MALT-lymphoma associated translocation|caspase-like protein|mucosa associated lymphoid tissue lymphoma translocation protein 1|paracaspase

  • Interactomes
  • Pathways
  • Diseases
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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