c-met/CEN7q FISH Probe
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More Files
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Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human stomach carcinoma (FFPE) stained with c-met/CEN7q FISH Probe. Human stomach carcinoma showed c-met gene amplification.
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human lung, adenosquamous cell carcinoma (FFPE) stained with c-met/CEN7q FISH Probe. Human lung, adenosquamous cell carcinoma showed no c-met gene amplification.
Hybridization position of the probes on the chromosome.
Hybridization position of the probes on the chromosome.
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Specifications
Product Description
Labeled FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology).
Probe 1
Name: c-met
Size: Approximately 270kb
Fluorophore: Texas Red
Location: 7q31Probe 2
Name: CEN7q
Size: Approximately 820kb
Fluorophore: FITC
Location: 7q11.21Probe Gap
The gap between two probes is approximately 51,200 kb.
Origin
Human
Source
Genomic DNA
Reactivity
Human
Form
Liquid
Notice
We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.
Regulation Status
For research use only (RUO)
Quality Control Testing
Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.
Supplied Product
DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe
Storage Instruction
Store at 4°C in the dark.
Note
Hybridization position of the probes on the chromosome. -
Applications
Fluorescent In Situ Hybridization (Cell)
Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human stomach carcinoma (FFPE) stained with c-met/CEN7q FISH Probe. Human stomach carcinoma showed c-met gene amplification.Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Human lung, adenosquamous cell carcinoma (FFPE) stained with c-met/CEN7q FISH Probe. Human lung, adenosquamous cell carcinoma showed no c-met gene amplification. -
Gene Info — MET
Entrez GeneID
4233Gene Name
MET
Gene Alias
AUTS9, HGFR, RCCP2, c-Met
Gene Description
met proto-oncogene (hepatocyte growth factor receptor)
Gene Ontology
HyperlinkGene Summary
The proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
HGF receptor|OTTHUMP00000069168|SF receptor|met proto-oncogene|met proto-oncogene tyrosine kinase|oncogene MET|scatter factor receptor
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Combination of Docetaxel Plus Savolitinib in Refractory Cancer Patients: A Report on Phase I Trial.
Kim ST, Lee S, Park M, Park SH, Park JO, Lim HY, Park YS, Kang WK, Gangolli EA, Shin H, Kim KM, Hollingsworth SJ, Mortimer PGS, Lee J.
Translational Oncology 2019 Jan; 12(4):597.
Application：Func, Human, Human gastric cancer.
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MET is overexpressed in microsatellite instability-high gastric carcinoma.
Sim J, Heo YJ, Bae H, Shin HC, Kim B, Cho J, Kim ST, Lee J, Kang WK, Kim KM.
Pathology, Research and Practice 2019 Mar; 215(3):433.
Application：FISH, Human, Human gastric carcinoma.
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Efficacy of continuous EGFR-inhibition and role of Hedgehog in EGFR acquired resistance in human lung cancer cells with activating mutation of EGFR.
Della Corte CM, Malapelle U, Vigliar E, Pepe F, Troncone G, Ciaramella V, Troiani T, Martinelli E, Belli V, Ciardiello F, Morgillo F.
Amino Acids 2017 Apr; 8(14):23020.
Application：FISH, Mouse, Mouse tumors (xenografts in mice of EGFR inhibitors resistant tumors).
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Integrated analysis of pediatric glioblastoma reveals a subset of biologically favorable tumors with associated molecular prognostic markers.
Korshunov A, Ryzhova M, Hovestadt V, Bender S, Sturm D, Capper D, Meyer J, Schrimpf D, Kool M, Northcott PA, Zheludkova O, Milde T, Witt O, Kulozik AE, Reifenberger G, Jabado N, Perry A, Lichter P, von Deimling A, Pfister SM, Jones DT.
Acta Neuropathologica 2015 May; 129(5):669.
Application：FISH-P, Human, Human glioblastoma.
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Co-existence of positive MET FISH status with EGFR mutations signifies poor prognosis in lung adenocarcinoma patients.
Tanaka A, Sueoka-Aragane N, Nakamura T, Takeda Y, Mitsuoka M, Yamasaki F, Hayashi S, Sueoka E, Kimura S.
Lung Cancer 2012 Jan; 75(1):89.
Application：FISH, Human, A549, H1975 cells, Lung adenocarcinoma.
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Combination of Docetaxel Plus Savolitinib in Refractory Cancer Patients: A Report on Phase I Trial.
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