APC recombinant monoclonal antibody, clone 5F2
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human and rat APC.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human APC.
Theoretical MW (kDa)
Calculated MW: 312,
Reactivity
Human, Rat
Form
Liquid
Purification
Affinity-chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western Blot analysis of Lane 1: Hela whole cell lysate; Lane 2: K562 whole cell lysate; Lane 3: SH-SY5Y whole cell lysate; Lane 4: A549 whole cell lysate; Lane 5: Rat Brain whole cell lysate.Immunohistochemistry
Immunohistochemistry image of APC recombinant monoclonal antibody, clone 5F2 diluted at 1:100 and staining in paraffin-embedded human breast cancer performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
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Gene Info — APC
Entrez GeneID
324Protein Accession#
P25054Gene Name
APC
Gene Alias
BTPS2, DP2, DP2.5, DP3, GS
Gene Description
adenomatous polyposis coli
Gene Ontology
HyperlinkGene Summary
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq
Other Designations
adenomatosis polyposis coli tumor suppressor
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Interactome
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Pathway
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Disease
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