APC recombinant monoclonal antibody, clone R06-2E4
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human APC.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human APC.
Theoretical MW (kDa)
Calculated MW: 312 k
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry
Immunofluorescence
Immunoprecipitation
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In 50mM Tris-Glycine, pH 7.4, (0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunocytochemistry
Immunocytochemistry analysis of APC (green) in LNcap using APC antibody,and DAPI(blue).Immunofluorescence
Immunoprecipitation
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Gene Info — APC
Entrez GeneID
324Protein Accession#
P25054Gene Name
APC
Gene Alias
BTPS2, DP2, DP2.5, DP3, GS
Gene Description
adenomatous polyposis coli
Gene Ontology
HyperlinkGene Summary
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq
Other Designations
adenomatosis polyposis coli tumor suppressor
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Interactome
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Pathway
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Disease
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