BAX recombinant monoclonal antibody, clone 6A7
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human BAX.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against synthetic peptides corresponding to amino acids 3-16 of murine BAX (CGSGEQLGSGGPTSS), amino acids 3-16 of human BAX (CGSGEQPRGGGPTSS), and amino acids 12-24 shared by BAX from both species (CGPTSSEQIMKTGA).
Reactivity
Human, Mouse, Rat
Form
Liquid
Conjugation
Unconjugated
Concentration
batch dependent
Isotype
IgG kappa
Recommend Usage
Immunohistochemistry
Immunoprecipitation
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS with 0.02% Proclin 300
Storage Instruction
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Paraffin-embedded sections) of human lung cancer with BAX recombinant monoclonal antibody, clone 6A7 (Cat # RAB03073) at 3 ug/mL.Immunoprecipitation
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Gene Info — BAX
Entrez GeneID
581Gene Name
BAX
Gene Alias
BCL2L4
Gene Description
BCL2-associated X protein
Omim ID
600040Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq
Other Designations
apoptosis regulator BAX
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Interactome
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Pathway
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Disease
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