Products

Western Blot

Western blot analysis of Lane 1: human thymus, Lane 2: lymph node and Lane 3: tonsil lysates with TNFRSF9 recombinant monoclonal antibody, clone 4B4-1-1 (Cat # RAB03046).

Immunohistochemistry

Immunofluorescence

Immunofluorescent staining of Jurkat cells with TNFRSF9 recombinant monoclonal antibody, clone 4B4-1-1 (Cat # RAB03046).
Immunofluorescence analysis of paraformaldehyde fixed Jurkat cells on Shi-fix™ coverslips stained with the chimeric r version of RAB03046 at 10 ug/ml for 1h followed by Alexa Fluor® 488 secondary antibody (2 ug/ml)- showing membrane staining. The nuclear stain is DAPI (blue). The isotype control was an unknown specificity antibody (3.0) followed by staining with Alexa Fluor® 488 secondary antibody.
(A) RAB03046
(B) DAPI
(C) Merged channels
(D) Isotype control

Enzyme-linked Immunoabsorbent Assay

Blocking

Flow Cytometry

Entrez GeneID

3604

Gene Name

TNFRSF9

Gene Alias

4-1BB, CD137, CDw137, ILA, MGC2172

Gene Description

tumor necrosis factor receptor superfamily, member 9

Omim ID

602250

Gene Ontology

Hyperlink

Gene Summary

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB. [provided by RefSeq

Other Designations

4-1BB ligand receptor|CD137 antigen|OTTHUMP00000001360|OTTHUMP00000044294|T cell antigen ILA|homolog of mouse 4-1BB|induced by lymphocyte activation (ILA)|interleukin-activated receptor, homolog of mouse Ly63|receptor protein 4-1BB