Doublecortin recombinant monoclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot analysis of rat brain (A) whole cell lysates with Doublecortin recombinant monoclonal antibody (Cat # RAB02406).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against recombinant Doublecortin.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein of human Doublecortin.
Theoretical MW (kDa)
41
Reactivity
Rat
Specificity
Recognizes endogenous levels of Doublecortin protein.
Form
Liquid
Purification
Immunogen affinity chromatography
Isotype
IgG
Recommend Usage
Western Blot (1:500-1:1000)
Storage Buffer
In 50mM Tris-Glycine, pH 7.4 (0.15M NaCl, 50% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C short term.
Aliquot and store at -20°C long term.
Avoid freeze-thaw cycles.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of rat brain (A) whole cell lysates with Doublecortin recombinant monoclonal antibody (Cat # RAB02406). -
Gene Info — DCX
Entrez GeneID
1641Protein Accession#
Q9ESI7Gene Name
DCX
Gene Alias
DBCN, DC, LISX, SCLH, XLIS
Gene Description
doublecortin
Gene Ontology
HyperlinkGene Summary
In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The protein encoded by this gene is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. The encoded protein contains two doublecortin domains, which bind microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene are a cause of X-linked lissencephaly. Multiple transcript variants encoding at least three different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000062892|doublecortex|doublin|lissencephalin-X
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Interactome
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Disease
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