LMNA recombinant monoclonal antibody, clone R07-1I5
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More Files
- More Functions
Western Blot
Western blot analysis of Lamin A/C in U251, Lncap, A549 lysates using Lamin A/C antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Lamin A/C antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
Immunocytochemistry
Immunocytochemistry staining of HeLa cells with LMNA recombinant monoclonal antibody, clone R07-1I5 (Cat # RAB01419).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human LMNA.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human LMNA.
Theoretical MW (kDa)
Calculated MW: 74 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunocytochemistry
Immunofluorescence
Immunohistochemistry (Frozen sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Western Blot
The optimal working dilution should be determined by the end user.Storage Buffer
In 50mM Tris-Glycine, pH 7.4, (0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lamin A/C in U251, Lncap, A549 lysates using Lamin A/C antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry analysis of paraffin-embedded Human breast cancer using Lamin A/C antibody.High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Immunohistochemistry (Frozen sections)
Immunocytochemistry
Immunocytochemistry staining of HeLa cells with LMNA recombinant monoclonal antibody, clone R07-1I5 (Cat # RAB01419).Immunofluorescence
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Gene Info — LMNA
Entrez GeneID
4000Protein Accession#
P02545Gene Name
LMNA
Gene Alias
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, PRO1
Gene Description
lamin A/C
Gene Ontology
HyperlinkGene Summary
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq
Other Designations
70 kDa lamin|OTTHUMP00000015843|OTTHUMP00000015848
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Interactome
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Pathway
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Disease
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