LMNA recombinant monoclonal antibody, clone 4H7
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More Files
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Immunohistochemistry
Immunohistochemical staining of human glioma cancer with LMNA recombinant monoclonal antibody, clone 4H7 (Cat # RAB04371) (diluated at 1:115).
Immunohistochemistry
Immunohistochemical staining of human breast cancer with LMNA recombinant monoclonal antibody, clone 4H7 (Cat # RAB04371) (diluated at 1:115).
Immunofluorescence
Immunofluorescent staining of Hela cells with LMNA recombinant monoclonal antibody, clone 4H7 (Cat # RAB04371) (diluated at 1:38). The secondary antibody was Alexa Fluor 488-congugated goat anti-rabbit IgG (green). Counter-stain DAPI was used (blue).
Immunoprecipitation
Immunoprecipitation analysis of HeLa cell lysate with LMNA recombinant monoclonal antibody, clone 4H7 (Cat # RAB04371).
Lane 1: rabbit control IgG, Lane 2: RAB04371 precipitates and Lane 3: Input (Hela whole cell lysate).
Flow Cytometry
Flow cytometric analysis of HeLa cells with LMNA recombinant monoclonal antibody, clone 4H7 (Cat # RAB04371) (diluated at 1:50; purple line) and negative control (green line).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human LMNA.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human LMNA.
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
ELISA
Flow Cytometry
Immunofluorescence (1:20-1:200)
Immunohistochemistry (1:50-1:200)
Immunoprecipitation (1:200-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemical staining of human glioma cancer with LMNA recombinant monoclonal antibody, clone 4H7 (Cat # RAB04371) (diluated at 1:115).Immunohistochemistry
Immunohistochemical staining of human breast cancer with LMNA recombinant monoclonal antibody, clone 4H7 (Cat # RAB04371) (diluated at 1:115).Immunofluorescence
Immunofluorescent staining of Hela cells with LMNA recombinant monoclonal antibody, clone 4H7 (Cat # RAB04371) (diluated at 1:38). The secondary antibody was Alexa Fluor 488-congugated goat anti-rabbit IgG (green). Counter-stain DAPI was used (blue).Immunoprecipitation
Immunoprecipitation analysis of HeLa cell lysate with LMNA recombinant monoclonal antibody, clone 4H7 (Cat # RAB04371).
Lane 1: rabbit control IgG, Lane 2: RAB04371 precipitates and Lane 3: Input (Hela whole cell lysate).Enzyme-linked Immunoabsorbent Assay
Flow Cytometry
Flow cytometric analysis of HeLa cells with LMNA recombinant monoclonal antibody, clone 4H7 (Cat # RAB04371) (diluated at 1:50; purple line) and negative control (green line). -
Gene Info — LMNA
Entrez GeneID
4000Protein Accession#
P02545Gene Name
LMNA
Gene Alias
CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, PRO1
Gene Description
lamin A/C
Gene Ontology
HyperlinkGene Summary
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq
Other Designations
70 kDa lamin|OTTHUMP00000015843|OTTHUMP00000015848
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Interactome
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Pathway
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Disease
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