ITK polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of ITK.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to internal region of human ITK.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Protein G purification
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
The ITK polyclonal antibody (Cat # PAB3429) is used in Western blot to detect ITK in CEM cell lysate. -
Gene Info — ITK
Entrez GeneID
3702Protein Accession#
ITK_HUMANGene Name
ITK
Gene Alias
EMT, LYK, MGC126257, MGC126258, PSCTK2
Gene Description
IL2-inducible T-cell kinase
Omim ID
186973Gene Ontology
HyperlinkGene Summary
This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq
Other Designations
homolog of mouse T-cell itk/tsk|tyrosine-protein kinase ITK/TSK|tyrosine-protein kinase LYK
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Interactome
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Pathway
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Disease
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Publication Reference
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Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A.
Brazin KN, Mallis RJ, Fulton DB, Andreotti AH.
PNAS 2002 Feb; 99(4):1899.
Application:IP, KA, WB, Human, Jurkat cells.
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Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity.
Hawkins J, Marcy A.
Protein Expression and Purification 2001 Jul; 22(2):211.
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Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q.
Janis EM, Siliciano JD, Isaac DD, Griffin CA, Hawkins AL, Kozak CA, Desiderio S.
Genomics 1994 Sep; 23(1):269.
Application:WB-Ce, WB-Tr, Human, Mouse, Mouse T lymphoid cells.
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Regulation of the tyrosine kinase Itk by the peptidyl-prolyl isomerase cyclophilin A.
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