CHRM3 polyclonal antibody
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More Files
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human smooth muscle with CHRM3 polyclonal antibody (Cat # PAB30942) shows moderate cytoplasmic positivity in muscle cells.
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant human CHRM3.
Immunogen
Recombinant protein corresponding to human CHRM3.
Sequence
LHNNSTTSPLFPNISSSWIHSPSDAGLPPGTVTHFGSYNVSRAAGNFSSPDGTTDDPLGGHTVWQV
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Antigen affinity purification
Isotype
IgG
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:20-1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (40% glycerol, 0.02% sodium azide).
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human smooth muscle with CHRM3 polyclonal antibody (Cat # PAB30942) shows moderate cytoplasmic positivity in muscle cells. -
Gene Info — CHRM3
Entrez GeneID
1131Protein Accession#
P20309Gene Name
CHRM3
Gene Alias
HM3
Gene Description
cholinergic receptor, muscarinic 3
Omim ID
118494Gene Ontology
HyperlinkGene Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. [provided by RefSeq
Other Designations
m3 muscarinic receptor|muscarinic acetylcholine receptor M3
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Interactome
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Pathway
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Disease
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Publication Reference
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Control of insulin secretion by cholinergic signaling in the human pancreatic islet.
Molina J, Rodriguez-Diaz R, Fachado A, Jacques-Silva MC, Berggren PO, Caicedo A.
Diabetes 2014 Aug; 63(8):2714.
Application：IF, IHC-Fr, Human, Human pancreas.
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Control of insulin secretion by cholinergic signaling in the human pancreatic islet.
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