MERTK/TYRO3 (phospho Y749/681) polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of Lane 1: EGF treated 3T3 cells, Lane 2: antigen-specific peptide treated 3T3 cells with MERTK/TYRO3 (phospho Y749/681) polyclonal antibody (Cat # PAB29209) at 1:500-1000 dilution.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human by MERTK/TYRO3 (phospho Y749/681) polyclonal antibody (Cat # PAB29209) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:500-1000 dilution.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic phosphopeptide of human MERTK/TYRO3.
Immunogen
Synthetic phosphopeptide (conjugated with KLH) corresponding to residues surrounding Y749/681 of human MERTK/TYRO3.
Host
Rabbit
Theoretical MW (kDa)
97
Reactivity
Human, Mouse, Rat
Specificity
This antibody detects endogenous levels of MER/TYRO3 only when phosphorylated at tyrosine 749/681.
Form
Liquid
Purification
Affinity purification
Recommend Usage
Immunohistochemistry (1:50-1:100)
Western Blot (1:500-1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (without Mg2+ and Ca2+), (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western blot analysis of Lane 1: EGF treated 3T3 cells, Lane 2: antigen-specific peptide treated 3T3 cells with MERTK/TYRO3 (phospho Y749/681) polyclonal antibody (Cat # PAB29209) at 1:500-1000 dilution.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining of human by MERTK/TYRO3 (phospho Y749/681) polyclonal antibody (Cat # PAB29209) without blocking peptide (A) or preincubated with blocking peptide (B) under 1:500-1000 dilution. -
Gene Info — TYRO3
Entrez GeneID
7301Protein Accession#
Q12866;Q06418Gene Name
TYRO3
Gene Alias
BYK, Brt, Dtk, FLJ16467, RSE, Sky, Tif
Gene Description
TYRO3 protein tyrosine kinase
Omim ID
600341Gene Ontology
HyperlinkOther Designations
Tyro3 protein tyrosine kinase (sea-related receptor tyrosine kinase)|tyrosine-protein kinase receptor TYRO3
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Gene Info — MERTK
Entrez GeneID
10461Protein Accession#
Q12866;Q06418Gene Name
MERTK
Gene Alias
MER, MGC133349, RP38, c-mer
Gene Description
c-mer proto-oncogene tyrosine kinase
Gene Ontology
HyperlinkGene Summary
This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq
Other Designations
MER receptor tyrosine kinase|STK kinase
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Interactome
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Disease
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