IRF3 polyclonal antibody
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of IRF3.
Immunogen
A synthetic peptide corresponding to human IRF3.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to IRF3.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunohistochemistry (1:50-1:100)
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from K-562 cells, using IRF3 polyclonal antibody (Cat # PAB18181).
Peptide "+" means "peptide blocking".Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using IRF3 polyclonal antibody (Cat # PAB18181).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of HeLa cells, using IRF3 polyclonal antibody (Cat # PAB18181).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — IRF3
Entrez GeneID
3661Protein Accession#
Q14653Gene Name
IRF3
Gene Alias
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Gene Description
interferon regulatory factor 3
Omim ID
603734Gene Ontology
HyperlinkGene Summary
IRF3 encodes interferon regulatory factor 3, a member of the interferon regulatory transcription factor (IRF) family. IRF3 is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Disease
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Publication Reference
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A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).
Biswas SK, Gangi L, Paul S, Schioppa T, Saccani A, Sironi M, Bottazzi B, Doni A, Vincenzo B, Pasqualini F, Vago L, Nebuloni M, Mantovani A, Sica A.
Blood 2006 Mar; 107(5):2112.
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Recognition of the measles virus nucleocapsid as a mechanism of IRF-3 activation.
tenOever BR, Servant MJ, Grandvaux N, Lin R, Hiscott J.
Journal of Virology 2002 Apr; 76(8):3659.
Application:WB-Tr, Human, A-549, HEK 293 cells.
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Downregulation of IRF-3 levels by ribozyme modulates the profile of IFNA subtypes expressed in infected human cells.
Yeow WS, Au WC, Lowther WJ, Pitha PM.
Journal of Virology 2001 Mar; 75(6):3021.
Application:WB-Tr, Human, 2fTGH, 2fTGH/IRF-7 cells.
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A distinct and unique transcriptional program expressed by tumor-associated macrophages (defective NF-kappaB and enhanced IRF-3/STAT1 activation).
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