IGLL1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against native IGLL1.
Immunogen
Native purified human IGLL1.
Host
Rabbit
Reactivity
Human, Monkey
Form
Liquid
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
Immunohistochemistry (Frozen sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (1% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunocytochemistry
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Gene Info — IGLL1
Entrez GeneID
3543Gene Name
IGLL1
Gene Alias
14.1, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2
Gene Description
immunoglobulin lambda-like polypeptide 1
Gene Ontology
HyperlinkGene Summary
The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
CD179b antigen|Pre-B lymphocyte-specific protein-2|immunoglobulin omega polypeptide chain|immunoglobulin-related 14.1 protein|lambda5
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Interactome
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Pathway
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Publication Reference
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B-cell lymphoma of large multilobated type: an immunohistochemical study of 8 cases and review of the literature.
Korkolopoulou P, Pangalis GA, Patsouris E, Boussiotis VA, Kittas C.
Leukemia & Lymphoma 1994 Mar; 13(1-2):151.
Application:IHC-P, Human, Human B-cell Lymphoma.
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Plasma cells producing lambda light chains are predominant in human gut and tonsils. An immunohistomorphometric study.
Faure GC, Tang JG, Mole C, Bene MC.
American Journal of Clinical Pathology 1990 Nov; 94(5):571.
Application:IF, Human, Duodenal mucosa.
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Biochemical characterization of amyloid derived from the variable region of the kappa light chain subgroup III.
Picken MM, Gallo GR, Pruzanski W, Frangione B.
Arthritis and Rheumatism 1990 Jun; 33(6):880.
Application:IHC, WB-Re, Human, N/A, Isolated fibrils and purified protein, Liver tissues.
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B-cell lymphoma of large multilobated type: an immunohistochemical study of 8 cases and review of the literature.
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