THPO (Human) Recombinant Protein
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Specification
Product Description
Human THPO partial recombinant protein with His tag in C-terminus expressed in HEK293 cells.
Sequence
DGSHMSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEGHHHHHH
Host
Human
Theoretical MW (kDa)
36.8
Form
Liquid
Preparation Method
Mammalian cell (HEK293) expression system
Purification
chromatographic
Purity
> 90% as determined by SDS-PAGE.
Activity
ED50 ≤ 10 ng/mL, measured by cell proliferation assay using MO7e human megakaryocytic leukemic cells.
Storage Buffer
Solution (0.25 mg/mL) containing 1X PBS, pH 7.4, 10% glycerol.
Storage Instruction
Store at 4°C for one weeks and should be stored at -20°C to -80°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid repeated freeze/thaw cycles. -
Applications
Functional Study
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Gene Info — THPO
Entrez GeneID
7066Protein Accession#
P40225Gene Name
THPO
Gene Alias
MGC163194, MGDF, MKCSF, ML, MPLLG, TPO
Gene Description
thrombopoietin
Gene Ontology
HyperlinkGene Summary
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. [provided by RefSeq
Other Designations
MPL ligand|c-mpl ligand|megakaryocyte colony-stimulating factor|megakaryocyte growth and development factor|megakaryocyte stimulating factor|myeloproliferative leukemia virus oncogene ligand|thrombopoietin nirs variant 1
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Interactome
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Disease
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