THPO (Human) Recombinant Protein
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Specification
Product Description
Human THPO recombinant protein expressed in HEK293 cells.
Sequence
SPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
Host
Human
Theoretical MW (kDa)
80-85
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purification
chromatographic
Purity
> 95% as determined by SDS-PAGE.
Activity
ED50 is 1.15 ng/mL, measured by the dose-dependent stimulation of the proliferation of MO7e cells.
Storage Buffer
Protein (0.74 mg/mL) was lyophilized from 1X PBS. Reconstitute the lyophilized powder in PBS containing 0.1% endotoxin-free recombinant HSA.
Storage Instruction
Lyophilized protein at room temperature for 3 weeks, should be stored at -20°C. Protein aliquots at 4°C for 2-7 days and should be stored at -20°C to -80°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).
Avoid repeated freeze/thaw cycles. -
Applications
Functional Study
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Gene Info — THPO
Entrez GeneID
7066Protein Accession#
P40225Gene Name
THPO
Gene Alias
MGC163194, MGDF, MKCSF, ML, MPLLG, TPO
Gene Description
thrombopoietin
Gene Ontology
HyperlinkGene Summary
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. [provided by RefSeq
Other Designations
MPL ligand|c-mpl ligand|megakaryocyte colony-stimulating factor|megakaryocyte growth and development factor|megakaryocyte stimulating factor|myeloproliferative leukemia virus oncogene ligand|thrombopoietin nirs variant 1
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Interactome
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Pathway
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Disease
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