EML4/ALK DY Translocation FISH Probe

Catalog # FT0001

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Size:100 uL
Price: USD $ 1,288.00
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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
Images
Fluorescent <i>In Situ</i> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Application

Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)

Human lung, adenosquamous cell carcinoma (FFPE) stained with EML4/ALK DY Translocation FISH Probe. Human lung, adenosquamous cell carcinoma showed no EML4/ALK DY Translocation.

Fluorescent <i>In Situ</i> Hybridization (Formalin/PFA-fixed paraffin-embedded sections)
Application

Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)

Human stomach carcinoma (FFPE) stained with EML4/ALK DY Translocation FISH Probe. Human stomach carcinoma showed no EML4/ALK DY Translocation.

QC Test

<br>Hybridization position of the probes on the chromosome.
Note


Hybridization position of the probes on the chromosome.


Hybridization position of the probes on the chromosome.

  • Specification

    Product Description

    Labeled FISH probes for identification of gene translocation using Fluorescent In Situ Hybridization Technique. (Technology)

    Probe 1

    Name: EML4
    Size: Approximately 1130kb
    Fluorophore: FITC
    Location: 2p22-p21

    Probe 2

    Name: ALK
    Size: Approximately 700kb
    Fluorophore: Texas Red
    Location: 2p23

    Probe Gap

    The gap between two probes is approximately 13,900 kb.

    Reactivity

    Human

    Form

    Liquid

    Notice

    We strongly recommend the customer to use FFPE FISH PreTreatment Kit 1 (Catalog #: KA2375 or KA2691) for the pretreatment of Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections.

    Regulation Status

    For research use only (RUO)

    Quality Control Testing

    Representative images of normal human cell (lymphocyte) stain with the dual color FISH probe. The left image is chromosomes at metaphase, and the right image is an interphase nucleus.

    Supplied Product

    DAPI Counterstain (1500 ng/mL ) 125 uL for each 100 uL FISH Probe

    Storage Instruction

    Store at 4°C in the dark.

    Note


    Hybridization position of the probes on the chromosome.

  • Applications

    Fluorescent In Situ Hybridization (Cell)

    Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)

    Human lung, adenosquamous cell carcinoma (FFPE) stained with EML4/ALK DY Translocation FISH Probe. Human lung, adenosquamous cell carcinoma showed no EML4/ALK DY Translocation.

    Fluorescent In Situ Hybridization (Formalin/PFA-fixed paraffin-embedded sections)

    Human stomach carcinoma (FFPE) stained with EML4/ALK DY Translocation FISH Probe. Human stomach carcinoma showed no EML4/ALK DY Translocation.
  • Gene Info — ALK

    Entrez GeneID

    238

    Gene Name

    ALK

    Gene Alias

    CD246, Ki-1, TFG/ALK

    Gene Description

    anaplastic lymphoma receptor tyrosine kinase

    Omim ID

    105590

    Gene Ontology

    Hyperlink

    Gene Summary

    The 2;5 chromosomal translocation is frequently associated with anaplastic large cell lymphomas (ALCLs). The translocation creates a fusion gene consisting of the ALK (anaplastic lymphoma kinase) gene and the nucleophosmin (NPM) gene: the 3' half of ALK, derived from chromosome 2, is fused to the 5' portion of NPM from chromosome 5. A recent study shows that the product of the NPM-ALK fusion gene is oncogenic. The deduced amino acid sequences reveal that ALK is a novel receptor protein-tyrosine kinase having a putative transmembrane domain and an extracellular domain. These sequences are absent in the product of the transforming NPM-ALK gene. ALK shows the greatest sequence similarity to LTK (leukocyte tyrosine kinase). ALK plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. [provided by RefSeq

    Other Designations

    ALK tyrosine kinase receptor|CD246 antigen|anaplastic lymphoma kinase (Ki-1)|anaplastic lymphoma kinase Ki-1

  • Gene Info — EML4

    Entrez GeneID

    27436

    Gene Name

    EML4

    Gene Alias

    C2orf2, DKFZp686P18118, ELP120, FLJ10942, FLJ32318, ROPP120

    Gene Description

    echinoderm microtubule associated protein like 4

    Omim ID

    607442

    Gene Ontology

    Hyperlink

    Other Designations

    -

  • Interactome
  • Disease
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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