PRDM16 FISH Probe
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Made to order FISH probes for identification of gene amplification using Fluorescent In Situ Hybridization Technique. (Technology)
For research use only (RUO)
DAPI Counterstain (1500 ng/mL ) 250 uL
Store at 4°C in the dark.
Fluorescent In Situ Hybridization (Cell)
Gene Info — PRDM16
KIAA1675, MEL1, MGC166915, PFM13
PR domain containing 16
The reciprocal translocation t(1;3)(p36;q21) occurs in a subset of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). This gene is located near the 1p36.3 breakpoint and has been shown to be specifically expressed in the t(1:3)(p36,q21)-positive MDS/AML. The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal PR domain. The translocation results in the overexpression of a truncated version of this protein that lacks the PR domain, which may play an important role in the pathogenesis of MDS and AML. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq
MDS1/EVI1-like|PR-domain zinc finger protein 16|transcription factor MEL1