OSCAR (Human) Recombinant Protein
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More Files
- More Functions
Enzyme-linked Immunoabsorbent Assay
Immobilized Human OSCAR, hFc Tag at 1 ug/mL (100 uL/Well) on the plate. Dose response curve for Biotinylated Anti-OSCAR Antibody, hFc Tag with the EC50 19.2 ng/mL determined by ELISA.
SEC-HPLC
The purity of Human OSCAR is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human OSCAR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
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Specification
Product Description
Human OSCAR (Q8IYS5-1, Asp19-Ser229) partial recombinant protein with hFc tag at C-Terminus expressed in HEK293 cells.
Sequence
Asp19-Asn229
Host
Human
Theoretical MW (kDa)
49.8
Form
Lyophilized
Preparation Method
Mammalian cell (HEK293) expression system
Purity
> 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
Endotoxin Level
< 1 EU per 1 ug of protein (determined by LAL method)
Activity
The EC50 was 19.2 ng/mL, messured by ELISA at 1 ug/mL.
Quality Control Testing
SEC-HPLC and Tris-Bis PAGE
SEC-HPLC
The purity of Human OSCAR is greater than 95% as determined by SEC-HPLC.
Tris-Bis PAGE
Human OSCAR on Tris-Bis PAGE under reduced condition. The purity is greater than 95%.
Recommend Usage
Biological Activity
ELISA
SDS-PAGE
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from sterile distilled Water is > 100 ug/mL
Storage Instruction
Store at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing.Note
Result of bioactivity analysis
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Applications
Enzyme-linked Immunoabsorbent Assay
Immobilized Human OSCAR, hFc Tag at 1 ug/mL (100 uL/Well) on the plate. Dose response curve for Biotinylated Anti-OSCAR Antibody, hFc Tag with the EC50 19.2 ng/mL determined by ELISA.Functional Study
SDS-PAGE
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Gene Info — OSCAR
Entrez GeneID
126014Protein Accession#
Q8IYS5-1Gene Name
OSCAR
Gene Alias
MGC33613, PIGR3
Gene Description
osteoclast associated, immunoglobulin-like receptor
Omim ID
606862Gene Ontology
HyperlinkGene Summary
Osteoclasts are multinucleated cells that resorb bone and are essential for bone homeostasis. This gene encodes an osteoclast-associated receptor (OSCAR), which is a member of the leukocyte receptor complex (LRC) protein family that plays critical roles in the regulation of both innate and adaptive immune responses. Different from the other LRC members, OSCAR expression is detected specifically in preosteoclasts or mature osteoclasts. OSCAR may be an important bone-specific regulator of osteoclast differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000067452|osteoclast associated receptor OSCAR-S1|osteoclast associated receptor OSCAR-S2|osteoclast-associated receptor|polymeric immunoglobulin receptor 3
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