GFAP monoclonal antibody, clone SPM507
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Specification
Product Description
Mouse monoclonal antibody raised against native human GFAP.
Immunogen
Native purified GFAP from porcine spinal cord.
Host
Mouse
Reactivity
Human, Pig
Form
Liquid
Purification
Protein A/G purification
Isotype
IgG1
Recommend Usage
Flow Cytometry (0.5-1 ug/million cells)
Immunofluorescence (1-2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.25-0.5 ug/mL)
Western Blot (0.5-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 10 mM PBS.
Storage Instruction
Store at 4°C. For long term storage store at -20°C to -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human cerebellum.Immunofluorescence
Flow Cytometry
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Gene Info — GFAP
Entrez GeneID
2670Protein Accession#
P14136Gene Name
GFAP
Gene Alias
FLJ45472
Gene Description
glial fibrillary acidic protein
Gene Ontology
HyperlinkGene Summary
This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq
Other Designations
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Gene Info — GFAP
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Interactome
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Disease
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Publication Reference
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Coexpression of intermediate filament polypeptides in human fetal and adult tissues.
Van Muijen GN, Ruiter DJ, Warnaar SO.
Laboratory Investigation 1987 Oct; 57(4):359.
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Co-expression of glial fibrillary acidic protein- and vimentin-type intermediate filaments in human astrocytomas.
Herpers MJ, Ramaekers FC, Aldeweireldt J, Moesker O, Slooff J.
Acta Neuropathologica 1986 Jan; 70(3-4):333.
Application:IF, IHC-Fr, Human, Human astroglial tumors.
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Monoclonal antibodies specific for glial fibrillary acidic (GFA) protein and for each of the neurofilament triplet polypeptides.
Debus E, Weber K, Osborn M.
Differentiation 1983 Jan; 25(2):193.
Application:ELISA, IF, IHC-Fr, IHC-P, Chicken, Human, Mouse, Rat, Human astrocytoma sections, IMR90 cells, NIH/3T3 cells, PtK2 cells, RD cells, Recombinant proteins, U333CG/343MG cells.
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Coexpression of intermediate filament polypeptides in human fetal and adult tissues.
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