BAX polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of BAX.
Immunogen
A synthetic peptide corresponding to residues surrounding T167 of human BAX.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody is specific to BAX.
Form
Liquid
Purification
Affinity purification
Concentration
1 mg/mL
Recommend Usage
Western Blot (1:500-1:1000)
Immunofluorescence (1:500-1:1000)
ELISA (1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, 150mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from HepG2 cells, using BAX polyclonal antibody (Cat # PAB18268).
Peptide "+" means "peptide blocking".Immunofluorescence
Immunofluorescence analysis of LoVo cells, using BAX polyclonal antibody (Cat # PAB18268).
Peptide "+" means "peptide blocking".Enzyme-linked Immunoabsorbent Assay
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Gene Info — BAX
Entrez GeneID
581Protein Accession#
Q07812Gene Name
BAX
Gene Alias
BCL2L4
Gene Description
BCL2-associated X protein
Omim ID
600040Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq
Other Designations
apoptosis regulator BAX
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Humanin peptide suppresses apoptosis by interfering with Bax activation.
Guo B, Zhai D, Cabezas E, Welsh K, Nouraini S, Satterthwait AC, Reed JC.
Nature 2003 May; 423(6938):456.
Application:IP, WB-Tr, Human, Monkey, Mouse, COS-7, HCT-116 cells, Mouse testes, SF268 cells.
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Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax.
Cuddeback SM, Yamaguchi H, Komatsu K, Miyashita T, Yamada M, Wu C, Singh S, Wang HG.
The Journal of Biological Chemistry 2001 Jun; 276(23):20559.
Application:IF, IP, WB-Ce, WB-Tr, Human, FL5.12, HEK 293T cells.
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Humanin peptide suppresses apoptosis by interfering with Bax activation.
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