S100B polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of S100B.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus human S100B.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
Western Blot (1:500)
Immunoprecipitation (1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In buffer containing 0.02% sodium azide
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunoprecipitation
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Gene Info — S100B
Entrez GeneID
6285Gene Name
S100B
Gene Alias
NEF, S100, S100beta
Gene Description
S100 calcium binding protein B
Omim ID
176990Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq
Other Designations
OTTHUMP00000174958|S-100 calcium-binding protein, beta chain|S100 beta|S100 calcium binding protein, beta (neural)|S100 calcium-binding protein, beta|S100 calcium-binding protein, beta (neural)
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Interactomes
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Diseases
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Publication Reference
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S-100 serum levels after minor and major head injury.
Rothoerl RD, Woertgen C, Holzschuh M, Metz C, Brawanski A.
The Journal of Trauma 1998 Oct; 45(4):765.
Application:ELISA, Human, Serum.
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Correlation of computed tomography findings and serum brain damage markers following severe head injury.
Raabe A, Grolms C, Keller M, Dohnert J, Sorge O, Seifert V.
Acta Neurochirurgica 1998 Jan; 140(8):787.
Application:ELISA, Human, Human serum.
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Serum S-100 protein, relationship to clinical outcome in acute stroke.
Abraha HD, Butterworth RJ, Bath PM, Wassif WS, Garthwaite J, Sherwood RA.
Annals of Clinical Biochemistry 1997 Jul; 34 ( Pt 4):366.
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S-100 serum levels after minor and major head injury.
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