AICDA polyclonal antibody
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AICDA.
Immunogen
A synthetic peptide corresponding to 14 amino acids near C-terminus of human AICDA.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
Anti-AID is human and mouse reactive.
Form
Liquid
Recommend Usage
Western Blot (1-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for three months. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of AICDA in Ramos whole cell lysate with AICDA polyclonal antibody (Cat # PAB12893) at 2 ug/mL in either the (A) absence or (B) presence of blocking peptide.Immunocytochemistry
Immunocytochemistry of AICDA in Ramos cells with AICDA polyclonal antibody (Cat # PAB12893) at 10 ug/mL . -
Gene Info — AICDA
Entrez GeneID
57379Protein Accession#
AAM95402Gene Name
AICDA
Gene Alias
AID, ARP2, CDA2, HIGM2
Gene Description
activation-induced cytidine deaminase
Gene Ontology
HyperlinkGene Summary
This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq
Other Designations
activation-induced deaminase|integrated into Burkitt's lymphoma cell line Ramos
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Advantages and disadvantages of cytidine deamination.
Cascalho M.
Journal of Immunology 2004 Jun; 172(11):6513.
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Expression of activation-induced cytidine deaminase in human B-cell non-Hodgkin lymphomas.
Greeve J, Philipsen A, Krause K, Klapper W, Heidorn K, Castle BE, Janda J, Marcu KB, Parwaresch R.
Blood 2003 May; 101(9):3574.
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Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme.
Muramatsu M, Kinoshita K, Fagarasan S, Yamada S, Shinkai Y, Honjo T.
Cell 2000 Sep; 102(5):553.
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Advantages and disadvantages of cytidine deamination.
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