ATM polyclonal antibody
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against partial recombinant ATM.
Immunogen
Recombinant protein corresponding to C-terminus of human ATM.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is specific to ATM.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Recombinant Protein.
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (50% glycerol, 0.05% sodium azide)
Storage Instruction
Store at -20°C or -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of ATM in HeLa whole cell lysate using ATM polyclonal antibody (Cat # PAB12480).Western Blot
Western blot analysis of ATM in HeLa whole cell lysate using ATM polyclonal antibody (Cat # PAB12480). (30 second exposure) .Immunofluorescence
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Gene Info — ATM
Entrez GeneID
472Protein Accession#
Q13315Gene Name
ATM
Gene Alias
AT1, ATA, ATC, ATD, ATDC, ATE, DKFZp781A0353, MGC74674, TEL1, TELO1
Gene Description
ataxia telangiectasia mutated
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
AT mutated|TEL1, telomere maintenance 1, homolog|ataxia telangiectasia mutated (includes complementation groups A, C and D)|ataxia telangiectasia mutated protein|human phosphatidylinositol 3-kinase homolog|serine-protein kinase ATM
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Interactomes
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Pathways
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Diseases
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Publication Reference
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The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species.
Gruhne B, Sompallae R, Marescotti D, Kamranvar SA, Gastaldello S, Masucci MG.
PNAS 2009 Jan; 106(7):2313.
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Nuclear export of NBN is required for normal cellular responses to radiation.
Vissinga CS, Yeo TC, Warren S, Brawley JV, Phillips J, Cerosaletti K, Concannon P.
Molecular and Cellular Biology 2009 Feb; 29(4):1000.
Application:WB, Mouse, NIH/3T3 cells.
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DDB1 maintains genome integrity through regulation of Cdt1.
Lovejoy CA, Lock K, Yenamandra A, Cortez D.
Molecular Biology of the Cell 2006 Nov; 26(21):7977.
Application:WB, Human, HeLa, U-2 OS cells.
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Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation.
Yang S, Jeong JH, Brown AL, Lee CH, Pandolfi PP, Chung JH, Kim MK.
The Journal of Biological Chemistry 2006 Sep; 281(36):26645.
Application:WB, Mouse, Mouse splenocytes.
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Senescence of human fibroblasts after psoralen photoactivation is mediated by ATR kinase and persistent DNA damage foci at telomeres.
Hovest MG, Brüggenolte N, Hosseini KS, Krieg T, Herrmann G.
Molecular Biology of the Cell 2006 Apr; 17(4):1758.
Application:IP, WB-Tr, Human, Human fibroblasts.
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The Epstein-Barr virus nuclear antigen-1 promotes genomic instability via induction of reactive oxygen species.
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