ATM recombinant monoclonal antibody, clone 4E11
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More Files
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Western Blot
Western blot analysis of Lane 1:Hela whole cell lysate, Lane 2: A549 whole cell lysate, Lane 3: PC3 whole cell lysate and Lane 4: HepG2 whole cell lysate with ATM recombinant monoclonal antibody, clone 4E11 (Cat # RAB04323).
Immunoprecipitation
Immunoprecipitation analysis of PC3 cell lysate with ATM recombinant monoclonal antibody, clone 4E11 (Cat # RAB04323).
Lane 1: rabbit control IgG, Lane 2: RAB04323 precipitates and Lane 3: Input (PC3 whole cell lysate).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human ATM.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human ATM.
Theoretical MW (kDa)
Calculated MW: 350 k
Reactivity
Human
Form
Liquid
Purification
Affinity chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunoprecipitation (1:200-1:1000)
Western Blot (1:500-1:5000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Lane 1:Hela whole cell lysate, Lane 2: A549 whole cell lysate, Lane 3: PC3 whole cell lysate and Lane 4: HepG2 whole cell lysate with ATM recombinant monoclonal antibody, clone 4E11 (Cat # RAB04323).Immunoprecipitation
Immunoprecipitation analysis of PC3 cell lysate with ATM recombinant monoclonal antibody, clone 4E11 (Cat # RAB04323).
Lane 1: rabbit control IgG, Lane 2: RAB04323 precipitates and Lane 3: Input (PC3 whole cell lysate).Enzyme-linked Immunoabsorbent Assay
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Gene Info — ATM
Entrez GeneID
472Protein Accession#
Q13315Gene Name
ATM
Gene Alias
AT1, ATA, ATC, ATD, ATDC, ATE, DKFZp781A0353, MGC74674, TEL1, TELO1
Gene Description
ataxia telangiectasia mutated
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
AT mutated|TEL1, telomere maintenance 1, homolog|ataxia telangiectasia mutated (includes complementation groups A, C and D)|ataxia telangiectasia mutated protein|human phosphatidylinositol 3-kinase homolog|serine-protein kinase ATM
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Interactome
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Pathway
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Disease
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