KLK3 polyclonal antibody
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of KLK3.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to C-terminus of human KLK3.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
ELISA (1:1000)
Western Blot (1:100-500)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of KLK3 polyclonal antibody (Cat # PAB4401) in mouse brain tissue lysate . KLK3 (arrow) was detected using the purified KLK3 polyclonal antibody (Cat # PAB4401) .Enzyme-linked Immunoabsorbent Assay
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Gene Info — KLK3
Entrez GeneID
354Protein Accession#
NP_001639;P07288Gene Name
KLK3
Gene Alias
APS, KLK2A1, PSA, hK3
Gene Description
kallikrein-related peptidase 3
Omim ID
176820Gene Ontology
HyperlinkGene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq
Other Designations
P-30 antigen|gamma-seminoprotein|kallikrein 3, (prostate specific antigen)|prostate specific antigen|semenogelase|seminin
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Polymorphic forms of prostate specific antigen and their interaction with androgen receptor trinucleotide repeats in prostate cancer.
Binnie MC, Alexander FE, Heald C, Habib FK.
The Prostate 2005 Jun; 63(4):309.
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Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression.
Habib FK, Ross M, Ho CK, Lyons V, Chapman K.
International Journal of Cancer 2005 Mar; 114(2):190.
Application:WB, Human, LNCaP cells.
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Expression of prostate specific membrane antigen in androgen-independent prostate cancer cell line PC-3.
Laidler P, Dulinska J, Lekka M, Lekki J.
Archives of Biochemistry and Biophysics 2005 Mar; 435(1):1.
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Polymorphic forms of prostate specific antigen and their interaction with androgen receptor trinucleotide repeats in prostate cancer.
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