Products

ChIP

Western Blot (Cell lysate)

Western blot was performed using nuclear extracts from HeLa cells (HeLa NE, 20 ug) and the CDC73 polyclonal antibody (Cat # PAB14104) at dilution 1 : 1,000 in TBS-Tween + 5% skimmed milk.

Western Blot (Cell lysate)

Western blot was performed using whole cell extracts (WCE) from drosophila larva (Lane 1) and drosophila adults (Lane 2) and the CDC73 polyclonal antibody (Cat # PAB14104) at dilution 1 : 1,000 in TBS-Tween + 5% skimmed milk.

Entrez GeneID

79577

Protein Accession#

Q6P1J9 (human)

Gene Name

CDC73

Gene Alias

C1orf28, FLJ23316, HPT-JT, HRPT2

Gene Description

cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)

Omim ID

145000 145001 607393 608266

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq

Other Designations

hyperparathyroidism 2 (with jaw tumor)|parafibromin