Mouse monoclonal antibody raised against native ITGAM.
Native purified ITGAM from human granulocytes.
Theoretical MW (kDa):
This antibody recognizes CD11b antigen (Mac-1), a 165 KDa transmembrane protein type 1 mainly expressed on monocytes, granulocytes and NK-cells. This antibody blocks (not completely) Mac-1-mediated neutrophil binding to fibrinogen.
The optimal working dilution should be determined by the end user.
In PBS, pH 7.4
Store at 4°C. Do not freeze. Aliquot to avoid repeated freezing and thawing.
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq