Epigenetics is the study of changes in gene activity that do not involve alterations to the genetic code but can still be passed on through cell division. These changes include epigenetic factors that modify the genome in two ways - DNA methylation and histone modification. Both of them affect gene transcription by turning genes on or off:

  • DNA methylation attaches methyl groups to the backbone of the DNA in specific places which may physically impede the binding of transcriptional proteins to the gene. Methylated DNA may also be bound by proteins that recruit other histone modifying proteins, thereby forming compact, inactive chromatin.
  • Histone modification occurs on the N-terminal tails of histones, changing how tightly or loosely they package DNA. If tightly wound, a gene may be hidden from transcriptional proteins, therefore un-accessible. If loosened, a gene that was formerly hidden may be turned on.



Antibody Product Showcase

Epigenetics Antibodies   Histone Modification Ab
3450+ antibodies for the study of heritable changes in gene function without DNA sequence change. 20 antibodies related to histone acetylation, methylation and phosphorylation.
 
Histone Deacetylase Antibodies   DNMT Antibodies
130+ antibodies against enzymes that remove acetyl groups from histones. 20+ antibodies for DNA methyltransferase family to transfer a methyl group to DNA.
 
ChIP Antibodies   Chromatin Regulation Antibodies
90+ specific antibodies for Chromatin Immuno-precipitation, CIITA, ESR1, H3F3A, HDAC1, and more. 1030+ antibodies for histone, histone demethylases and chromatin structure modification.
 
 
 

Epigenetic Kits

 
 

Abnova Kit Advantages

  • Quick and efficient
  • Innovative colorimetric and fluorometric assays
  • Identify gene amplification, loss, and translocation
  • Very senstive, requiring very low amounts
  • Controls are conveniently included for quantification
  • Strip microplate format makes the assay flexible: manual or high throughput
  • Simple, reliable, and consistent assay conditions
  • In situ histone phosphorylation and methylation kits available (whole cell-based detection)
 
Note - These advantages apply to the majority of our kits. Please refer to product protocols for specific details.