TTR recombinant monoclonal antibody, clone 3F6
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human TTR.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human TTR.
Reactivity
Human
Form
Liquid
Purification
Affinity-chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
Store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemistry image of TTR recombinant monoclonal antibody, clone 3F6 diluted at 1:100 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
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Gene Info — TTR
Entrez GeneID
7276Protein Accession#
P02766Gene Name
TTR
Gene Alias
HsT2651, PALB, TBPA
Gene Description
transthyretin
Omim ID
176300Gene Ontology
HyperlinkGene Summary
This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq
Other Designations
prealbumin, amyloidosis type I|thyroxine-binding prealbumin
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Interactome
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Disease
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