AGT recombinant monoclonal antibody, clone 8A9
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human AGT.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to full length human AGT.
Reactivity
Human
Form
Liquid
Purification
Affinity-chromatography
Isotype
IgG
Recommend Usage
ELISA
Immunohistochemistry (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (150mM NaCl, 50% glycerol and 0.02% sodium azide)
Storage Instruction
store at -20 °C or -80 °C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunohistochemistry image of AGT recombinant monoclonal antibody, clone 8A9 diluted at 1:100 and staining in paraffin-embedded human kidney tissue performed on a Leica BondTM system.Enzyme-linked Immunoabsorbent Assay
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Gene Info — AGT
Entrez GeneID
183Protein Accession#
P01019Gene Name
AGT
Gene Alias
ANHU, FLJ92595, FLJ97926, SERPINA8
Gene Description
angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq
Other Designations
OTTHUMP00000035878|alpha-1 antiproteinase, antitrypsin|angiotensin I|angiotensin II|angiotensinogen|pre-angiotensinogen|serine (or cysteine) proteinase inhibitor
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Interactome
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Pathway
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Disease
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