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Immunofluorescence

Immunofluorescent staining of U251 cells with GABRA1 recombinant monoclonal antibody, clone 1F4 (Cat # RAB03478).
Immunofluorescence analysis of paraformaldehyde U251 cells fixed on Shi-fix™ coverslips stained with the chimeric r version of RAB03478 at 10 ug/mL for 1h followed by Alexa Fluor® 488 secondary antibody (2 ug/mL), showing membrane staining. The nuclear stain is DAPI (blue). The isotype control was an unknown specificity antibody followed by staining with Alexa Fluor® 488 secondary antibody.
(A) RAB03478
(B) DAPI
(C) Merged channels
(D) Isotype control

Crystallography

Entrez GeneID

2554

Gene Name

GABRA1

Gene Alias

ECA4, EJM

Gene Description

gamma-aminobutyric acid (GABA) A receptor, alpha 1

Omim ID

137160 606904

Gene Ontology

Hyperlink

Gene Summary

This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq

Other Designations

OTTHUMP00000160870