CAV1 recombinant monoclonal antibody, clone R05-6C3
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More Files
- More Functions
Western Blot
Western blot analysis of Caveolin1 in Hela lysates using human Caveolin-1 recombinant monoclonal antibody, clone R05-6C3 (Cat # RAB01699).
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with Caveolin1 recombinant monoclonal antibody, clone R05-6C3 (Cat # RAB01699). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human Caveolin-1.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human Caveolin-1
Theoretical MW (kDa)
Calculated MW: 20 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunofluorescence (1:50-1:200)
Immunohistochemistry (1:50-1:100)
Immunoprecipitation (1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Caveolin1 in Hela lysates using human Caveolin-1 recombinant monoclonal antibody, clone R05-6C3 (Cat # RAB01699).Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with Caveolin1 recombinant monoclonal antibody, clone R05-6C3 (Cat # RAB01699). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.Immunohistochemistry (Frozen sections)
Immunocytochemistry
Immunoprecipitation
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Gene Info — CAV1
Entrez GeneID
857Protein Accession#
Q03135Gene Name
CAV1
Gene Alias
BSCL3, CAV, CGL3, MSTP085, VIP21
Gene Description
caveolin 1, caveolae protein, 22kDa
Omim ID
601047Gene Ontology
HyperlinkGene Summary
The scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene. [provided by RefSeq
Other Designations
OTTHUMP00000025031|caveolae protein, 22-kD|caveolin 1|caveolin 1 caveolae protein, 22kD|caveolin 1, alpha isoform|caveolin 1, beta isoform|caveolin-1 beta isoform protein|cell growth-inhibiting protein 32
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Interactome
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Pathway
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Disease
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