CYP19A1 recombinant monoclonal antibody, clone R04-3D8
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against synthetic peptide of human Aromatase.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against a synthetic peptide corresponding to human Aromatase
Theoretical MW (kDa)
Calculated MW: 58 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Immunoprecipitation(1:20)
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM Tris-Glycine, pH 7.4 (0.15 M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of Aromatase in MCF-7, C6, 3T3, Hela lysates using human Aromatase recombinant monoclonal antibody, clone R04-3D8 (Cat # RAB01591).Immunoprecipitation
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Gene Info — CYP19A1
Entrez GeneID
1588Protein Accession#
P11511Gene Name
CYP19A1
Gene Alias
ARO, ARO1, CPV1, CYAR, CYP19, MGC104309, P-450AROM
Gene Description
cytochrome P450, family 19, subfamily A, polypeptide 1
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq
Other Designations
OTTHUMP00000162543|aromatase|cytochrome P450, family 19|cytochrome P450, subfamily XIX (aromatization of androgens)|estrogen synthetase|flavoprotein-linked monooxygenase|microsomal monooxygenase
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Interactome
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Disease
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