STAT5B recombinant monoclonal antibody, clone R08-2I8
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More Files
- More Functions
Western Blot
Western blot analysis of STAT5b in Raw264.7, PC-12 lysates using STAT5b antibody.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with STAT5B recombinant monoclonal antibody, clone R08-2I8 (Cat # RAB01208).
Immunocytochemistry
Immunocytochemistry analysis of STAT5b (green) in Hela using STAT5b antibody,and DAPI(blue).
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Specification
Product Description
Rabbit recombinant monoclonal antibody raised against human STAT5B.
Antibody Species
Rabbit
Immunogen
Original antibody is raised against recombinant protein corresponding to human STAT5b.
Theoretical MW (kDa)
Calculated MW: 90 kD
Reactivity
Human
Form
Liquid
Purification
Affinity purification
Isotype
IgG
Recommend Usage
Western Blot
Immunohistochemistry (Frozen sections)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunocytochemistry
Immunofluorescence
Immunoprecipitation
The optimal working dilution should be determined by the end user.Storage Buffer
In 50mM Tris-Glycine pH 7.4 (0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA)
Storage Instruction
Store at 4°C. For longer storage, aliquot and store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Western blot analysis of STAT5b in Raw264.7, PC-12 lysates using STAT5b antibody.Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemical staining (Formalin-fixed paraffin-embedded sections) of human breast cancer with STAT5B recombinant monoclonal antibody, clone R08-2I8 (Cat # RAB01208).Immunohistochemistry (Frozen sections)
Immunocytochemistry
Immunocytochemistry analysis of STAT5b (green) in Hela using STAT5b antibody,and DAPI(blue).Immunofluorescence
Immunoprecipitation
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Gene Info — STAT5B
Entrez GeneID
6777Protein Accession#
P51692Gene Name
STAT5B
Gene Alias
STAT5
Gene Description
signal transducer and activator of transcription 5B
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq
Other Designations
transcription factor STAT5B
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Interactome
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Pathway
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Disease
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