NRP1 polyclonal antibody
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More Files
- More Functions
Western Blot (Transfected lysate)
Western blot of COS-7 cells untransfected (lane 1) or transfected with HA-tagged mouse neuropilin-1 (lane 2). Blots were probed with NRP1 polyclonal antibody (Cat # PAB7896).
Immunofluorescence
Immunocytochemical double labeling using NRP1 polyclonal antibody (Cat # PAB7896) in COS-7 cells mock transfected (A) or transfected with NRP1 constructs (B). The specificity of the binding in (B) was demonstrated by using NRP1 peptide, in the presence of the NRP1 polyclonal antibody (Cat # PAB7896) (C).
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of NRP1.
Immunogen
A synthetic peptide corresponding to the a1 CUB domain of human NRP1.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This sequence is highly conserved in rat and mouse neuropilin-1, and has low homology to neuropilin-2.
Form
Liquid
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:2000)
Immunocytochemistry (1:50)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (50% glycerol, 1 mg/mL BSA, 0.05% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Transfected lysate)
Western blot of COS-7 cells untransfected (lane 1) or transfected with HA-tagged mouse neuropilin-1 (lane 2). Blots were probed with NRP1 polyclonal antibody (Cat # PAB7896).Immunocytochemistry
Immunofluorescence
Immunocytochemical double labeling using NRP1 polyclonal antibody (Cat # PAB7896) in COS-7 cells mock transfected (A) or transfected with NRP1 constructs (B). The specificity of the binding in (B) was demonstrated by using NRP1 peptide, in the presence of the NRP1 polyclonal antibody (Cat # PAB7896) (C).Enzyme-linked Immunoabsorbent Assay
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Gene Info — NRP1
Entrez GeneID
8829Protein Accession#
O14786Gene Name
NRP1
Gene Alias
BDCA4, CD304, DKFZp686A03134, DKFZp781F1414, NP1, NRP, VEGF165R
Gene Description
neuropilin 1
Omim ID
602069Gene Ontology
HyperlinkGene Summary
NRP1 is a membrane-bound coreceptor to a tyrosine kinase receptor for both vascular endothelial growth factor (VEGF; MIM 192240) and semaphorin (see SEMA3A; MIM 603961) family members. NRP1 plays versatile roles in angiogenesis, axon guidance, cell survival, migration, and invasion.[supplied by OMIM
Other Designations
OTTHUMP00000020818|OTTHUMP00000020820|OTTHUMP00000020821|neuropilin-1|transmembrane receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation.
Saban MR, Backer JM, Backer MV, Maier J, Fowler B, Davis CA, Simpson C, Wu XR, Birder L, Freeman MR, Soker S, Hurst RE, Saban R.
American Journal of Physiology. Renal Physiology 2008 Jul; 295(1):F60.
Application：IF, IHC, Mouse, Mouse bladder urothelium.
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Structural and functional relation of neuropilins.
Nakamura F, Goshima Y.
Advances in Experimental Medicine and Biology 2002 Jan; 515:55.
Application：WB-Tr, Monkey, COS-7 cells.
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Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors.
Takahashi T, Fournier A, Nakamura F, Wang LH, Murakami Y, Kalb RG, Fujisawa H, Strittmatter SM.
Cell 1999 Oct; 99(1):59.
Application：IF, IP, WB-Tr, Chicken, Human, Chick E7 DRG neurons, HEK 293T cells.
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VEGF receptors and neuropilins are expressed in the urothelial and neuronal cells in normal mouse urinary bladder and are upregulated in inflammation.
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