MUTYH polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of MUTYH.
Immunogen
A synthetic peptide corresponding to human MUTYH.
Sequence
C-HISTDAHSLNSAAQ
Host
Goat
Theoretical MW (kDa)
60, 59.1, 57.5, 57.4
Reactivity
Human
Specificity
This antibody is expected to recognize all reported isoforms (NP_0.36354.1, NP_001041636.1, NP_001041637.1, NP_001041638.1, NP_001041639.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Quality Control Testing
Antibody Reactive Against Synthetic Peptide.
Recommend Usage
ELISA (1:16000)
Western Blot (0.1-0.3 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
MUTYH polyclonal antibody (Cat # PAB6606) (0.1 ug/mL) staining of human bone marrow lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MUTYH
Entrez GeneID
4595Protein Accession#
NP_0.36354.1;NP_001041636.1;NP_001041637.1;NP_001041638.1;NP_001041639.1Gene Name
MUTYH
Gene Alias
MGC4416, MYH
Gene Description
mutY homolog (E. coli)
Gene Ontology
HyperlinkGene Summary
This gene encodes a DNA glycosylase involved in oxidative DNA damage repair. The enzyme excises adenine bases from the DNA backbone at sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine, a major oxidatively damaged DNA lesion. The protein is localized to the nucleus and mitochondria. Mutations in this gene result in heritable predisposition to colon and stomach cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
A/G-specific adenine DNA glycosylase|OTTHUMP00000009096|OTTHUMP00000009098|OTTHUMP00000009101|OTTHUMP00000009102|mutY homolog
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Interactome
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Pathway
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Disease
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Publication Reference
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Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage.
Slupska MM, Baikalov C, Luther WM, Chiang JH, Wei YF, Miller JH.
Journal of Bacteriology 1996 Jul; 178(13):3885.
Application:WB-Ce, WB-Tr, Human, HeLa cells.
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Cloning and sequencing a human homolog (hMYH) of the Escherichia coli mutY gene whose function is required for the repair of oxidative DNA damage.
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