ERBB3 polyclonal antibody

Catalog # PAB26836

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Size:100 ug
Price: USD $ 329.00
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Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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Immunofluorescence
Application

Immunofluorescence

Immunofluorescence staining of methanol-fixed MCF-7 cells using ERBB3 polyclonal antibody (Cat # PAB26836, red).

  • Specifications

    Product Description

    Rabbit polyclonal antibody raised against synthetic peptide of ERBB3.

    Immunogen

    A synthetic peptide (conjugated with KLH) corresponding to residues surrounding Y1289 of human ERBB3.

    Sequence

    Q-G-Yp-E-E

    Host

    Rabbit

    Theoretical MW (kDa)

    185

    Reactivity

    Human

    Form

    Liquid

    Purification

    Affinity chromatography

    Concentration

    1 mg/mL

    Recommend Usage

    Immunofluorescence (1:100-1:200)
    The optimal working dilution should be determined by the end user.

    Storage Buffer

    In PBS, 150 mM NaCl, pH 7.4 (50% glycerol, 0.02% sodium azide)

    Storage Instruction

    Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.

    Note

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

  • Applications

    Immunofluorescence

    Immunofluorescence staining of methanol-fixed MCF-7 cells using ERBB3 polyclonal antibody (Cat # PAB26836, red).
  • Gene Info — ERBB3

    Entrez GeneID

    2065

    Protein Accession#

    P21860

    Gene Name

    ERBB3

    Gene Alias

    ErbB-3, HER3, LCCS2, MDA-BF-1, MGC88033, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3

    Gene Description

    v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

    Omim ID

    190151 607598

    Gene Ontology

    Hyperlink

    Gene Summary

    This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq

    Other Designations

    erbB-3|lethal congenital contracture syndrome 2|v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

  • Interactomes
  • Pathways
  • Diseases
Contact Info
  • +1-909-264-1399
    +1-909-992-0619
    Toll Free : +1-877-853-6098
  • +1-909-992-3401
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