AHCY polyclonal antibody
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More Files
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Western Blot (Cell lysate)
Western blot analysis of AHCY polyclonal antibody (Cat # PAB2577) in 293 cell line lysates (35 ug/lane).AHCY (arrow) was detected using the purified polyclonal antibody.
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Specifications
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of AHCY.
Immunogen
A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human AHCY.
Host
Rabbit
Reactivity
Human
Form
Liquid
Purification
Ammonium sulfate precipitation
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10-50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of AHCY polyclonal antibody (Cat # PAB2577) in 293 cell line lysates (35 ug/lane).AHCY (arrow) was detected using the purified polyclonal antibody.Immunohistochemistry
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Gene Info — AHCY
Entrez GeneID
191Protein Accession#
NP_000678;P23526Gene Name
AHCY
Gene Alias
SAHH
Gene Description
S-adenosylhomocysteine hydrolase
Omim ID
180960Gene Ontology
HyperlinkGene Summary
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000030684|adenosylhomocysteinase
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability.
Li QS, Cai S, Fang J, Borchardt RT, Kuczera K, Middaugh CR, Schowen RL.
Biochemistry 2008 Apr; 47(17):4983.
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Homocysteine-mediated expression of SAHH, DNMTs, MBD2, and DNA hypomethylation potential pathogenic mechanism in VSMCs.
Yideng J, Jianzhong Z, Ying H, Juan S, Jinge Z, Shenglan W, Xiaoqun H, Shuren W.
DNA and Cell Biology 2007 Aug; 26(8):603.
Application：WB-Ce, Human, Human vascular smooth muscle cells.
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Isozyme and DNA analysis of human S-adenosyl-L-homocysteine hydrolase (AHCY).
Arredondo-Vega FX, Charlton JA, Edwards YH, Hopkinson DA, Whitehouse DB.
Annals of Human Genetics 1989 May; 53(2):157.
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Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability.
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