AHCY MaxPab mouse polyclonal antibody (B01)
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More Files
- More Functions
Western Blot (Transfected lysate)
Western Blot analysis of AHCY expression in transfected 293T cell line (H00000191-T01) by AHCY MaxPab polyclonal antibody.
Lane 1: AHCY transfected lysate(47.52 KDa).
Lane 2: Non-transfected lysate.
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Specifications
Product Description
Mouse polyclonal antibody raised against a full-length human AHCY protein.
Immunogen
AHCY (NP_000678.1, 1 a.a. ~ 432 a.a) full-length human protein.
Sequence
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
Host
Mouse
Reactivity
Human
Interspecies Antigen Sequence
Mouse (97); Rat (97)
Quality Control Testing
Antibody reactive against mammalian transfected lysate.
Storage Buffer
No additive
Storage Instruction
Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Note
For IHC and IF applications, antibody purification with Protein A will be needed prior to use.
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Applications
Western Blot (Transfected lysate)
Western Blot analysis of AHCY expression in transfected 293T cell line (H00000191-T01) by AHCY MaxPab polyclonal antibody.
Lane 1: AHCY transfected lysate(47.52 KDa).
Lane 2: Non-transfected lysate.
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Gene Info — AHCY
Entrez GeneID
191GeneBank Accession#
NM_000687.1Protein Accession#
NP_000678.1Gene Name
AHCY
Gene Alias
SAHH
Gene Description
S-adenosylhomocysteine hydrolase
Omim ID
180960Gene Ontology
HyperlinkGene Summary
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000030684|adenosylhomocysteinase
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Interactomes
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Pathways
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Diseases
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Publication Reference
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Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.
Kenneth N Maclean, Hua Jiang, Whitney N Phinney, Bailey M Mclagan, James R Roede, Sally P Stabler.
Molecular Genetics and Metabolism 2021 Feb; 132(2):128.
Application：WB-Ti, Mouse, Mouse liver.
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Sex-specific dysregulation of cysteine oxidation and the methionine and folate cycles in female cystathionine gamma-lyase null mice: a serendipitous model of the methylfolate trap.
Jiang H, Hurt KJ, Breen K, Stabler SP, Allen RH, Orlicky DJ, Maclean KN.
Biology Open 2015 Aug; 4(9):1154.
Application：WB, Mouse, Liver.
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Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis.
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